DePaul Hall opened in 1961 as Niagara University's science building. In addition to classrooms and faculty offices, it houses laboratories for chemistry, biology, and psychology.
It was named for the founder of the Congregation of the Mission, St. Vincent de Paul. St. Vincent was born in France in 1581 and lived in Paris from 1617 until his death in 1660. He co-founded the Daughters of Charity with St. Louise de Marillac, and addressed the plight of the poor by establishing orphanages, foster care programs, soup kitchens, volunteer programs and aid programs for prisoners.